Diagnosis & Biomarkers

I was diagnosed January 28, 2015 with stage 4 colon cancer, at the ripe age of 37. It was determined to be a mucinous adenocarcinoma. I am MSS (micro satellite stable), KRAS wild type (not mutated).

I presented with a single, small tumor (1cm) in the Sigmoid colon (descending) and multiple metastasis (15-18) in the liver. Lesions in the liver ranged in size from 1-2cm up to over 7cm and were located in both lobes of the liver. We later found out there was a metastasis on the right ovary as well.

My resection May 19, 2015 consisted of removing over 7 inches of colon and 32 lymph nodes. Colon was reattached without need for an ostomy. I had a couple of wedge resections from the liver and a few spots treated with radio ablation. This was a staged resection, the purpose of this first resection was to clean out the left side of the liver and preserve as much liver as possible for future surgeries. I also underwent a full hysterectomy  during this first surgery.

Pathology results from this first resection revealed the following:

2 of 32 lymph nodes were diseased

a single metastasis was found on the right ovary

Next generation sequencing (NGS) indicated KRAS wild type (NO MUTATION), no NRAS mutation, no BRAF mutation.

Mucinous adenocarcinoma identified

Future Caris testing on tissue from the second staged resection from December 1, 2015 revealed MSS (micro satellite stable).